Our research is aimed at understanding the causes, course of illness and outcomes of mood disorders, such as bipolar disorder and depression.  We use many approaches to answer these questions, including neuroimaging, genomics, and stress neuroendocrinology.  Specific goals include developing biomarkers to predict treatment response and characterizing neurobiological mechanisms leading to different illness trajectories.  We are located in the Department of Psychiatry at Brigham & Women’s Hospital, Harvard Medical School.