Our research focuses on bettering our understanding of mood disorders, such as bipolar disorder and depression.  We aim to discover more about how mood disorders develop and progress with the ultimate goal of improving outcomes.

Oxidative Stress and Bipolar Disorder Trajectories (CURRENTLY ENROLLING)

We are studying brain mechanisms related to changes in mood with aging in bipolar disorder. Results of this study may help us find new treatments to improve mood outcomes with aging. This study is funded by the National Institute of Mental Health.

Effect of Biological Sex and Circulating Sex Hormones on Oxidative Stress in Bipolar Disorder (CURRENTLY ENROLLING)

In this study, we are examining sex differences in brain mechanisms related to bipolar disorder. This study is funded by the Brigham & Women’s Hospital Program for Interdisciplinary Neuroscience, Women’s Brain Initiative Pilot.

Linking the roles of HPA-axis response and GABAergic function in women (CURRENTLY ENROLLING)

We are studying the relationship between brain function and stress response in women. This study is funded by the Brigham & Women’s Hospital Connors Center, WHISPR Pilot.

Neuroimaging biomarkers of lithium response in bipolar disorder

In this study, we used high-resolution 7 Tesla neuroimaging to examine brain features related to response to lithium treatment in bipolar disorder. We found differences in brain activation in prefrontal and limic regions in response to a feaful faces task in people who responded to lithium compared to people who did not respond. These results provide a foundaton for future studies to identify brain features that can predict lithium response. This study was funded by the National Institute of Mental Health.

Publication: A pilot fMRI study of lithium response in bipolar disorder. Rootes-Murdy K, Glazer K, Mondimore FM, Goes FS, PGBD Study, Zandi PP, Bakker A, DePaulo JR Jr, Mahon PB. (2019) Psychiatry Res Neuroimaging. Apr; 286:1-3.